San Francisco 49ers fortified their defense in the 2025 NFL Draft, focusing heavily on bolstering their defensive line. Key picks included massive defensive tackle Alfred Collins, whose size presents potential value in run defense, although some analysts debate his fit in a passing league. The team also selected linebacker Nick Martin, noted for his explosive speed and tackling ability, albeit concerns linger about his coverage skills. Upton Stout, a smaller cornerback, was also selected, indicating a strategy shift towards more dynamic coverage in the secondary. Collectively, these picks reflect a commitment to enhancing defensive strength ahead of the upcoming season.